COPROCESSED EXCIPIENTS PDF

Co-processed excipients have been developed to handle changes in the physical properties of particles at sub-particle levels. By co-processing two excipients. A co-processed excipient is any combination of 2 or more excipients obtained by physical co-processing that does not lead to the formation of. co-processed excipients ppt. 1. 1; 2. CO-PROCESSED Presented by- Under the guidance ofMr. Bhaskar N. Bangar Dr. N. H. Aloorkar.

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Table 1 Composition of atorvastatin calcium tablets. Drug excipients compatibility study The drug-excipients interaction study was carried out using method descried in Cartensen and analysis done using FTIR spectrophotometer [ 13 ]. Stability studies The stability studies were carried out for the optimized formulation. The protocol of stability studies was in compliance with ICH guidelines for stability testing intended for the zone IVa.

Saha S, Shahiwala AF Multifunctional coprocessed excipients for improved tabletting performance. The co-processed excipients were formed using granulation technique. It is clear from the evaluation results that coprocessing improved the flow properties. Blend containing the drug along with the excipients was weighed and it was kept in an open cylinder which was placed on graph sheet. Mostly binding and blending properties are enhanced by this technique than the formulations involving the individual excipients.

Evaluation of mouth dissolving tablets Developed tablets were evaluated for usual tablet tests such as weight variation, hardness, friability, drug content.

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The mucilage was evaluated for flow properties, Swelling index, loss on drying and FTIR study [ 910 ]. The constants of Kawakita equation can be used to estimate the flow and cohesiveness properties of powders. The excipienst rate of atorvastatin calcium has been enhanced by using the co-processed excipients of acacia and CaCO 3.

Mouth dissolving tablet; Terbutaline sulphate; Coprocessed excipient; Ocimum bascilium ; Superdisintegrant. Developed tablets were evaluated for usual tablet tests such as weight variation, hardness, friability, drug content.

Co-processed Excipients

However, the direct compression process is highly influenced by functionality of parent excipients. Recent research on co-processed excipients for direct compression – A Review. It is exipients as Loss on drying: The more is the binder used, the more is the disintegration time for the tablets. Mouth dissolving tablet of Terbutaline sulphate containing Ocimum bascilium as a superdisintegrant was prepared successfully. The direct compression method is most widely accepted process for hydrophobic drugs to be formulated into tablet dosage forms.

A similar functional group of Terbutaline was observed in Figure 4.

Formulation and Evaluation of Coprocessed Excipient for Mouth Dissolving Formulation

Then they were subjected to different tapings of 25, 50, 75 and and the volume was noted after each step of tapings as v. The new trend of using plant derived materials has evoked tremendous interest in pharmaceutical industry. The flow properties may be improved by the method of coprocessing which minimizes number of excipients and improves its functionality. In coprocessing the substance interacted at sub particle level that comprises the particle shape, size that gives improved flow property.

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As both brittle and plastic excipients were used, problems such as capping, lamination, sensitivity to moisture and other compaction problems can be overcome. All materials used in the study complied with pharmaceutical and analytical standards.

Co-processed Excipients

The sample was poured through the funnel until the apex of the conical pile touched the tip of the funnel. The functionality of excipients means improvement in flow properties, compressibility, and better dilution potential.

Coprocesxed 2 Micromeritic properties of co-processing excipients formulated with different ratios of acacia mucilage and calcium carbonate. Dissolution test was carried out at 75 rpm using ml of 6.

The agitation was provided by shaft of mechanical stirrer at rpm. The direct compression technique involves the compression of a dry blend of powders that comprises drugs and various excipients. The excipients acacia and CaCO 3 were used in the present study.

However, in presence of co-processed excipients, the drug showed good flow properties.

The granules of the formulations with pure acacia F 1 and pure CaCO 3 F 2 showed passable flow properties.